Bioorthogonal reagents with advanced properties
1 March 2017
We have discovered that 1,2,4-triazines bearing pyridinium substituents have interesting properties making these bioorthogonal reagents superior in many aspects.
- S. J. Siegl, R. Dzijak, A. Vázquez, R. Pohl, M. Vrabel, The discovery of pyridinium 1,2,4-triazines with enhanced performance in bioconjugation reactions, Chemical Science 2017, 8, 3593-3598, https://doi.org/10.1039/C6SC05442K
Organelle-specific prodrug activation
29 December 2020
Many drug targets are located in particular cellular compartments known as organelles. Traditional medicinal chemistry approaches focus on bioavailability and tissue targeting,…
Our work was highlighted on ChemistryViews
9 September 2020
Our work was highlighted on ChemistryViews. Congratulations to all the authors!