Organelle-specific prodrug activation
Many drug targets are located in particular cellular compartments known as organelles. Traditional medicinal chemistry approaches focus on bioavailability and tissue targeting, but rarely address drug delivery to specific cellular organelles. Our team has demonstrated that the delivery and release of biologically active molecules from inactive precursors can be achieved in an organelle-specific manner.
Read more in the IOCB web article.
- R. Dzijak, J. Galeta, A. Vázquez, J. Kozák, M. Matoušová, H. Fulka, M. Dračínský, M. Vrábel, Structurally Redesigned Bioorthogonal Reagents for Mitochondria-Specific Prodrug Activation, JACS Au 2020, https://pubs.acs.org/doi/full/10.1021/jacsau.0c00053