New bioorthogonal reagents and reactions
Our group is dedicated to improving existing bioorthogonal reagents and pioneering new reactions in the field. To achieve this, we integrate principles of synthetic organic chemistry with biological methodologies, providing a complex understanding of molecular characteristics and behavior.
Application of the developed tools
Our objective is to leverage the developed reagents and reactions to label and investigate both small molecules and biomolecules across a range of cellular systems. Specifically, we are focused on labeling small molecule drugs to elucidate their distribution within living cells.
Bioconjugations in immunotherapy
In this project, we employ the tools of bioorthogonal chemistry to tailor the surfaces of immune cells, including NK cells, with diverse targeting moieties. These engineered immune cells exhibit enhanced efficacy in eradicating cancer cells compared to their unmodified counterparts.