Check out our chapter about the application of CuAAC reaction for peptide and protein modification written by Agustina, Anna, and Milan and published now within the Science of Synthesis series.
- La Venia, A.; Kovalová, A.; Vrabel, M. 2.3 CuAAC in Protein Conjugation. In Click Chemistry, 1st edition ed.; Georg Thieme Verlag KG: Stuttgart, 2022; Vol. 2021/4. https://doi.org/10.1055/sos-SD-235-00062
Read the main achievements of our work within the ERC-funded project SWEETOOLS which are now highlighted on the CORDIS website.
Our SWEETOOLS articles
Milan and Michal attended the 55th Advances in Organic, Bioorganic and Pharmaceutical Chemistry Conference (Liblice 2021), where Michal presented his work on a poster.
Great food, great location, great science and everything finally in person!
Veronika Šlachtová received the prestigious IOCB postdoctoral fellowship to work on cycloadditions of triazinium salts.
In collaboration with our ex-visiting student Francesca Mancuso and the group of Rosaria Gitto at the University of Messina, Italy we published new work on Vibrio cholerae carbonic anhydrase inhibitors.
- Mancuso, F., De Luca, L., Bucolo, F., Vrabel, M., Angeli, A., Capasso, C., Supuran, C.T. and Gitto, R. (2021), 4-Sulfamoylphenylalkylamides as Inhibitors of Carbonic Anhydrases Expressed in Vibrio cholerae. ChemMedChem. https://doi.org/10.1002/cmdc.202100510
New PhD student Marek Chovanec joins the group to work on organelle-targeted bioorthogonal reactions.
Welcome and good luck!
Veronika Šlachtová, a new student from Olomouc joins the group as a postdoc.
Jáchym Hrušák, a student from the Charles University joins our group to work on his Bachelor thesis.
Welcome and good luck!
High school student Klára Wildmannová from Brno joins the group for a 6-week internship to get her first hands-on experience in laboratory work.
Our new work on the synthesis of TCO and BCN containing peptides and their application in bioorthogonal labeling was just accepted in Chemistry—A European Journal.
- La-Venia, A., Dzijak, R., Rampmaier, R. and Vrabel, M. (2021), An Optimized Protocol for the Synthesis of Peptides Containing trans-cyclooctene and Bicyclononyne Dienophiles as Useful Multifunctional Bioorthogonal Probes. Chem. Eur. J. Accepted Author Manuscript. https://doi.org/10.1002/chem.202102042
Congratulation to all authors and big thanks to Agustina who made the great job during her postdoctoral stay in the group!