Superfluorogenic coumarin-tetrazine probes

In our work published as a hot paper within “The Young Chemists 2020 Special Collection” of Chemistry, we describe the influence of various substituents on the photophysical properties of dyes formed in reaction of coumarin-tetrazines with two different dienophiles. These highly fluorogenic reactions can be used for various bioimaging applications in live cells.

• J. Galeta, R. Dzijak, J. Obořil, M. Dračínský, M. Vrabel, A Systematic Study of Coumarin–Tetrazine Light‐Up Probes for Bioorthogonal Fluorescence Imaging, Chem. Eur. J. 2020, 26, 9945, https://doi.org/10.1002/chem.202001290

Check out our videos showing how the reaction works in the cells in real time!

• Download: Video 1, Video 2, Video 3 

Thanks also to Paul Reyes for creating the colorful Cover Feature. COVID is not going to stop us!